How to prepare Indomethacine Drug?

Dose of indomethacine = 10 mg/Kg

How to prepare?

10 mg = 1 kg = 1000 g

So, 1 mg = 100 g

If the rat body weight is 200 g, we need 2 mg of indomethacine

If i want to inject 100 microliter for each rat, perhaps i have 7 rats, s0;

2 mg x 7 = 14 mg = 700 microliter which 100 microliter for each rat

Better to prepare extra;

2 mg x 10 = 20 mg = 1 ml

As a conclusion, 20 mg of indomethacine will be dissolved in 1 ml 0.5% Sodium Bicarbonate

Now, let us see how 0.5% Sodium Bicarbonate was prepared;

0.5 g of Sodium Bicarbonate dissolved in 100 ml deionised water

0.05 g of Sodium Bicarbonate dissolved in 10 ml deionised water

0.025g of Sodium Bicarbonate dissolved in 5 ml deionised water


Easy right?

Now, you can try to prepare the same dose of indomethacine for the rat with body weight 300 g.

What's the answer?